The laboratory animal studies on tcdd and ra exposure indicated high incidences of congenital developmental malformations . in our previously study , we analyzed gene expression profile in igf gene family of tcdd - and ra - reduced fetal rats as well as cells and found antiestrogenic effect of tcdd and ra on igf genes 我們應用ra對不同發(fā)育時期的胎鼠進行誘導,構(gòu)建骨骼發(fā)育畸形大鼠動物模型,研究遺傳因素決定的先天畸形個體間對環(huán)境因素作用的易感性,闡明igfs家族成員在骨骼發(fā)育畸形大鼠中的作用。
Poiycyclic aromatic hydrocarbons ( pah ) are priority trace organic pollutants in the clrtap ( convention on long - range transboundary air poliution ) pops ( persistent organic poilutants ) protocol . both laboratory experiments and fie1d surveys unequivocally demonstrated that pah adversely affect estuarine and marine organisms . pah are implicated in the development of iesions and tumors in fish , they produce biochemical disruptions and cell damage that iead to mutations , developmental malformations and cancel although many marine organisms do not exhibit acute responses to pah " exposure , but suffer sublethal effects 本論文以湄洲灣海域和廈門西海域養(yǎng)殖區(qū)為研究區(qū)域,采用現(xiàn)代分析技術(shù),從分子水平上系統(tǒng)研究了多環(huán)芳烴( pah )在海水、沉積物、養(yǎng)殖魚類中的含量分布:通過現(xiàn)場實驗,實驗室暫養(yǎng)、投毒和恢復實驗系統(tǒng)測定了養(yǎng)殖魚類的肝臟、膽汁、鰓、全血等不同器官、組織的生化指標及養(yǎng)殖魚類肝臟、膽汁的化學指標,探討了這些指標對水環(huán)境多環(huán)芳烴污染的生物指示作用。